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Aug 31 (Reuters) – Drugmakers have begun shipping copycat versions of Takeda Pharmaceutical’s drug Vyvanse, which is expected to offset the ongoing shortage of the ADHD medicine in the United States.

The U.S. Food and Drug Administration had said on Monday it has approved generic versions of Vyvanse from 11 drugmakers after Takeda’s exclusivity over the drug expired on Aug. 24. Copycats of the drug come in capsules and chewable tablets, ranging between 10 milligrams to 70 milligram doses.

U.S.-based drugmakers Mallinckrodt and Viatris , UK-based Hikma Pharmaceuticals and Indian drugmaker Sun Pharmaceutical Industries confirmed on Thursday they began shipping their generic versions of the drug, which is also approved for a binge-eating disorder in adults.

The generic drugmakers said they are working with the Drug Enforcement Administration (DEA) as the drugs are classified as a controlled substance.

Controlled substances are medications that can cause physical and mental dependence, and have restrictions on how the prescriptions can be refilled.

“We will be working closely with the DEA to request and secure additional quota to increase our production following this approval,” Mallinckrodt said.

Since October, the FDA has warned of an ongoing shortage of Teva Pharmaceutical Industries Ltd’s Adderall, after the Israel-based drugmaker had flagged intermittent manufacturing delays.

That shortage led to a jump in demand for Vyvanse, which combined with manufacturing issues, has resulted in a shortage of Takeda’s drug.

(Reporting by Sriparna Roy in Bengaluru; Editing by Krishna Chandra Eluri)

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Older adults with ADHD are at a greater risk of traffic tickets and car crashes than their counterparts without the condition.

Researchers in five states across the US studied more than 2,800 adults between 65 and 79 years old, of which 75 had been diagnosed with ADHD. They found adults with the condition were more than twice as likely to get a traffic ticket and 74 percent more likely to get into a car accident. 

Based on their findings, the researchers called for better treatment options for older adults with ADHD, which affects more than 40 million Americans and has led to twice as many prescriptions for medications to treat the condition, like Adderall in recent years. 

‘These findings suggest that effective interventions to improve the diagnosis and clinical management of ADHD among older adults are warranted to promote safe mobility and healthy aging,’ the study authors wrote. 

Older adults with ADHD were more than twice as likely to get a parking ticket and three-quarters more likely to get into a car crash than their counterparts without the condition

Prescriptions for Adderall surged during the COVID-19 pandemic. In February 2020, just before the virus erupted across America, the drug made up 1.1% of drugs. By September 2022, the figure had more than doubled to 2.31% of all scripts written

Researchers recruited 2,232 drivers ages 65 to 79 between 2015 and 2017 in five areas: Aurora, Colorado; Ann Arbor, Michigan; San Diego, California; Baltimore, Maryland; and Cooperstown, New York. Women made up 53 percent of the study population, while men made up 47 percent. 

Of the participants, 41.6 percent were 65 to 69 years old, 34.8 percent were 70 to 74 years old, and 23.6 percent were 75 to 79 years old. The 75 adults with ADHD made up 2.6 percent of the study population. In addition, 11.3 percent reported having anxiety, while 19.8 percent had depression.

The researchers found older adults with ADHD had a 102 percent increased risk of self-reported traffic tickets and a 74 percent greater likelihood of self-reported car crashes. They were also seven percent more likely to report hard braking, or slamming on the brakes with little warning.

The team speculated this could be due to adults with ADHD being more impatient, overestimating their driving abilities, having decreased reaction time and paying less attention. 

A limitation of the study was that it was based solely on participants self-reporting, which could have led to bias and inaccurate results. The researchers also did not know how severe each participant’s ADHD symptoms were. 

Attention deficit/hyperactivity disorder (ADHD) is a common disorder that is typically diagnosed in childhood, but recent years have seen an increase in adult diagnoses.

Neuroscientists have not pinned down a cause for ADHD, though genetics is believed to play a major role. 

The primary symptoms of ADHD, which typically manifest before age 12, include inattention and hyperactive-impulsive behavior. People with ADHD may be continuously fidgety, unable to concentrate on a given task, talk excessively, interrupt others and be easily distracted, among other symptoms. 

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hyperactive or impulsive; impacts girls as much or more than boys. Amphetamines were widely prescribed in the 1950s and 1960s for depression and obesity, but were changed to Schedule II of the Controlled Substances Act in 1971 after the potential for abuse and addiction was recognized 1. Methamphetamine is a central nervous system stimulant similar to the drug study was designed to see if amphetamine or methylphenidate posed a higher risk, especially when amphetamine seems to produce some of the same brain changes seen in psychosis. It is the piece of the puzzle people with ADHD may be missing that inhibits and blocks them from reaching their potential. Take some more activated charcoal on the day of the test. Cinacalcet: